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Published on: April 7, 2023
[Chromosome karyotype and Y chromosome microdeletion analysis in 133 idiopathic male infertile patients]
Yan Ji1, Hong-jia Xu, Jian-chu Huang
1Department of Obstetrics and Gynecology, Huizhou Municipal Central Hospital, Huizhou 516000, China. jiyanqurong163@com
Objective:
To explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients.
Methods:
Karyotypic analysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis.
Results:
Of the 133 patients, 25 (18.80%) were found to have chromosome abnormalities, and 12 (9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism. Four patients had both chromosomal abnormalities and Y chromosome microdeletions.
Conclusion:
The chromosomal abnormalities and Y chromosome microdeletions may play an important role in idiopathic male infertility, suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in such patients.
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