Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reflections in the Shadow of Death: Values, Relationships, and the Search for the Meaning in the End-of-Life Care.

Omega·2026
Same author

Human cytomegalovirus (HHV5) reactivation during lactation.

Microbial pathogenesis·2026
Same author

The role of FMR1 mRNA structure on the efficiency of non-canonical translation of toxic polyglycine protein.

Nucleic acids research·2026
Same author

Perceived and received support among patients with cancer receiving palliative care in Malta: a qualitative study.

Scientific reports·2026
Same author

Detection of HPV DNA in Cervical Intraepithelial Neoplasia Using In Situ Hybridization.

Journal of clinical medicine·2026
Same author

Experimental and CFD Investigation of inlet fin influence on compressor stability and performance.

Scientific reports·2026

Related Experiment Video

Updated: Jun 16, 2026

Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster
04:59

Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster

Published on: March 28, 2025

Structural diversity of triplet repeat RNAs.

Krzysztof Sobczak1, Gracjan Michlewski, Mateusz de Mezer

  • 1Laboratory of Cancer Genetics, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland.

The Journal of Biological Chemistry
|February 18, 2010
PubMed
Summary

RNA triplet repeats form distinct structures, including hairpins and G-quadruplexes. This structural diversity influences their function and susceptibility to degradation, providing insights into RNA biology.

Related Experiment Videos

Last Updated: Jun 16, 2026

Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster
04:59

Single Nucleotide Polymorphism-sensitive FISH Detection of Locus-specific Ribosomal RNA Transcription in Drosophila melanogaster

Published on: March 28, 2025

Area of Science:

  • Molecular Biology
  • RNA Structure
  • Genomics

Background:

  • Tandem trinucleotide repeats are common in the human transcriptome.
  • The functions of these RNA repeats are poorly understood and likely depend on their structures.

Purpose of the Study:

  • To investigate the structural properties of various triplet repeat transcripts in RNA.
  • To understand how sequence and structure influence RNA repeat function.

Main Methods:

  • Biochemical structural analysis of 17-repetition triplet repeat transcripts.
  • UV-monitored structure melting and circular dichroism spectroscopy.
  • Assessment of susceptibility to serum nucleases.

Main Results:

  • Four distinct structural classes of RNA triplet repeats were identified.
  • Specific motifs formed stable hairpins (e.g., CNG) or G-quadruplexes (e.g., AGG, UGG).
  • Structural features correlated with nuclease susceptibility.

Conclusions:

  • RNA triplet repeats exhibit diverse structures, influencing their stability and function.
  • This study provides a structural basis for understanding the roles of RNA triplet repeats.