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Apatite containing aspartic acid for selective protein loading.

M Hafiz Uddin¹, T Matsumoto, S Ishihara

¹Department of Oromaxillofacial Regeneration, Osaka University, 1-8 Yamada-oka, Suita, 565-0871, Japan.

Journal of Dental Research

|February 18, 2010

Summary

Hydroxyapatite (HAp) modified with aspartic acid (Asp) shows altered properties, enabling selective basic protein loading. This makes Asp-modified HAp a promising carrier for drug delivery applications, particularly for basic proteins like bFGF and BMP.

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Area of Science:

Biomaterials Science
Materials Chemistry
Nanotechnology

Background:

Hydroxyapatite (HAp) is a key biomaterial for drug delivery and tissue engineering.
Physico-chemical modifications are crucial for developing advanced HAp carrier materials.
Acidic amino acids, like aspartic acid (Asp), show affinity for both HAp and basic proteins.

Purpose of the Study:

To investigate the effects of aspartic acid (Asp) on the physico-chemical properties of hydroxyapatite (HAp).
To evaluate the potential of Asp-modified HAp as a carrier for basic proteins in drug delivery.

Main Methods:

Synthesis of HAp in the presence of varying concentrations of Asp.
Characterization of HAp crystallinity and physico-chemical properties.
Protein adsorption studies using basic proteins.

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Main Results:

Asp modification modulated HAp crystallinity and physico-chemical properties.
Asp was trapped within HAp crystals, not incorporated into the lattice.
Asp-modified HAp exhibited selective loading capacity for basic proteins.

Conclusions:

Asp-modified HAp demonstrates potential as a bioactive carrier material.
This material is particularly suitable for the targeted delivery of basic proteins such as bFGF and BMP.