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A probable association of acute dystonia with gemifloxacin administration

Dinesh Dutt Sharma1, Ashish Aggarwal, Ravi C Sharma

  • 1Department of Psychiatry, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Indian Journal of Medical Sciences
|February 18, 2010
PubMed

Insights

Gemifloxacin, a broad-spectrum antibiotic, can cause rare neuropsychiatric side effects. This case highlights acute dystonia as a potential adverse event in patients receiving gemifloxacin therapy.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Infectious Diseases

Background:

  • Gemifloxacin is a fluoroquinolone antibiotic known for broad-spectrum activity and once-daily dosing.
  • Fluoroquinolones are associated with a range of neuropsychiatric adverse effects.

Observation:

  • A 36-year-old woman was treated with gemifloxacin for an upper respiratory tract infection.
  • Acute dystonia developed on the third day of gemifloxacin therapy.

Findings:

  • This case presents a potential link between gemifloxacin use and the development of acute dystonia.
  • Neuropsychiatric side effects of fluoroquinolones, including dystonia, warrant clinical attention.

Implications:

  • Clinicians should be aware of the risk of acute dystonia when prescribing gemifloxacin.
  • Further investigation into the specific mechanisms of gemifloxacin-induced dystonia may be warranted.

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