Related Experiment Video
Updated: Jun 16, 2026

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
Published on: November 21, 2025
Mesangial cells initiate compensatory tubular cell hypertrophy
I Sinuani1, I Beberashvili, Z Averbukh
1Assaf Harofeh Medical Center Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel. sinuanii@asaf.health.gov.il
Abstract:
Unilateral nephrectomy results in compensatory renal growth, in which both the size and the functional capacity of the remaining kidney are increased. The functional adaptation to the removal of the contralateral kidney consists mostly of an increase in the glomerular filtration rate of the remaining kidney, and hypertrophy of cells comprising the nephron, mainly of the proximal tubular cells. Although the phenomenon of single kidney hypertrophy has been known for the past thousand years and despite intensive research over the past century, the mechanism of this process still remains unclear. The present article reviews the role of mesangial cells in compensatory renal hypertrophy.
Related Concept Videos
Cellular Adaptation II: Hypertrophy
Heart Failure II: Pathophysiology
Cellular Adaptation III: Hyperplasia
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion
Hormonal Regulation
Reabsorption and Secretion in the DCT and Collecting Duct
The distal part of the DCT, along with the...
