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Updated: Jun 16, 2026

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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
Published on: January 2, 2015
Tau kinase I overexpression induces dentate gyrus degeneration
Jesús Avila1, Elena Gómez de Barreda, Tobias Engel
1Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain. javila@cbm.uam.es
Neuro-Degenerative Diseases
|February 18, 2010
Abstract:
Familial Alzheimer gene mutations result in a signaling mechanism that converges, downstream, in the activation of GSK3 activity. We have generated a GSK3 transgenic mouse model to study the consequences of GSK3 activation. In this model, dentate gyrus is degenerated in a process in which phosphorylated tau can be involved.
