Related Experiment Video
Updated: Jun 16, 2026

09:53
Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
Published on: April 23, 2019
Responses to odors in occupational environments
Pamela H Dalton1, Cristina Jaén
1Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104-3308, USA. dalton@monell.org
Current Opinion in Allergy and Clinical Immunology
|February 18, 2010
Summary
Airborne chemicals and irritants in the workplace negatively impact worker health and productivity. Addressing indoor air quality and psychosocial factors is crucial for managing building-related symptoms and chemical intolerance.
Area of Science:
- Environmental Health
- Occupational Medicine
- Toxicology
Background:
- Airborne chemicals causing odor and irritation can hinder workforce productivity and health.
- Symptoms can occur even in individuals without pre-existing chemical sensitivity.
Purpose of the Study:
- To review the impact of airborne chemicals, odors, and irritants on occupational health.
- To explore the relationship between indoor air quality, psychosocial factors, and building-related symptoms.
- To evaluate the efficacy of using pleasant odors to improve workplace mood and productivity.
Main Methods:
- Literature review of studies on odor and irritant-induced symptoms in occupational settings.
- Analysis of the role of indoor air quality and psychosocial factors.
- Assessment of research on workplace odor interventions.
Main Results:
- Poor indoor air quality combined with psychosocial factors contributes to building-related complaints and exacerbates chemical intolerance.
- Current research does not support the use of pleasant odors to enhance workplace productivity or mood.
Conclusions:
- Managing worker responses to workplace odors and irritants is essential for health and well-being.
- Harmonizing occupational exposure limits by regulatory bodies is urgently needed.
- Effective risk communication and worker education are vital to prevent misperceptions of risk and associated illness.
Related Concept Videos
Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Tactile and Chemical Senses
Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex. This...

