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Related Experiment Video

Updated: Jun 16, 2026

Generating Genetically Modified Plasmodium berghei Sporozoites

Generating Genetically Modified Plasmodium berghei Sporozoites

Published on: May 5, 2023

[A fifth plasmodium that can cause malaria].

Bjørn Myrvang¹

¹Kompetansesenter for import- og tropesykdommer, Oslo universitetssykehus, Ullevål 0407 Oslo, Norway. bjmy@uus.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke

|February 18, 2010

Summary

Plasmodium knowlesi malaria, a zoonotic disease, is increasingly diagnosed in Southeast Asia. Early diagnosis and appropriate treatment are crucial for preventing severe illness and potential death from this Plasmodium infection.

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Area of Science:

Tropical medicine
Infectious diseases
Parasitology

Context:

Plasmodium knowlesi, a simian malaria parasite, has emerged as a significant human pathogen in Southeast Asia since 2004.
Human infections are concentrated in Malaysian Borneo, with increasing reports among travelers.

Purpose:

To provide a concise overview of the epidemiology, clinical presentation, diagnostic methods, and treatment strategies for Plasmodium knowlesi infections.
To highlight the diagnostic challenges and potential severity of P. knowlesi malaria.

Summary:

Human P. knowlesi infections typically present with malaria-like symptoms, characterized by quotidian fever spikes (24-hour intervals).
Early microscopic diagnosis can be challenging, often mistaken for Plasmodium malariae, potentially leading to delayed or incorrect treatment.
Severe cases can mimic Plasmodium falciparum malaria, with a risk of fatal outcomes. Treatment varies from chloroquine for mild cases to parenteral artesunate or quinine for severe infections.

Impact:

This overview aids clinicians in recognizing and managing P. knowlesi malaria, improving patient outcomes.
Understanding the epidemiology and clinical spectrum is vital for public health surveillance and control efforts in endemic regions.
Awareness among travelers is important to prevent misdiagnosis and ensure timely medical attention.