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Updated: Jun 16, 2026

An R-Based Landscape Validation of a Competing Risk Model
Published on: September 16, 2022
Confidence limits on one-stage model parameters in benchmark risk assessment
Brooke E Buckley1, Walter W Piegorsch, R Webster West
1Department of Mathematics, Northern Kentucky University, Highland Heights, KY 41099, USA.
Abstract:
In modern environmental risk analysis, inferences are often desired on those low dose levels at which a fixed benchmark risk is achieved. In this paper, we study the use of confidence limits on parameters from a simple one-stage model of risk historically popular in benchmark analysis with quantal data. Based on these confidence bounds, we present methods for deriving upper confidence limits on extra risk and lower bounds on the benchmark dose. The methods are seen to extend automatically to the case where simultaneous inferences are desired at multiple doses. Monte Carlo evaluations explore characteristics of the parameter estimates and the confidence limits under this setting.
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