Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria
Matthew J Panzner1, Arpaporn Deeraksa, Alyssa Smith
1Department of Chemistry, University of Akron, Akron, OH 44325-3601, USA.
European Journal of Inorganic Chemistry
|February 18, 2010
Abstract:
A series of N-heterocyclic carbene silver complexes have been synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burkholderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assays demonstrated the exceptional efficacy of the complexes against these potentially weaponizable pathogens.
