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Related Experiment Videos

Increased plasma noncortisol glucocorticoid activity in open-angle glaucoma.

G R McCarty1, B Schwartz

  • 1Department of Ophthalmology, New England Medical Centre Hospitals, Boston, Massachusetts 02111.

Investigative Ophthalmology & Visual Science
|April 1, 1991
PubMed
Summary

Glaucoma patients exhibit higher plasma glucocorticoid activity due to non-cortisol hormones, suggesting a hypothalamic-pituitary-adrenal axis disturbance. This finding highlights a potential link between open-angle glaucoma and altered steroid hormone levels.

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Area of Science:

  • Endocrinology
  • Ophthalmology
  • Biochemistry

Background:

  • Glucocorticoids play crucial roles in physiological processes.
  • Elevated glucocorticoid activity has been implicated in various health conditions.
  • The specific role of plasma glucocorticoid activity in open-angle glaucoma remains unclear.

Purpose of the Study:

  • To compare total biologic plasma glucocorticoid activity in normal, ocular hypertensive, and open-angle glaucoma patients.
  • To investigate the contribution of cortisol versus non-cortisol glucocorticoids to plasma activity in these groups.
  • To explore potential associations between open-angle glaucoma and the hypothalamic-pituitary-adrenal (HPA) axis.

Main Methods:

  • Utilized a glucocorticoid receptor-based competitive binding assay to measure total biologic plasma glucocorticoid activity.

Related Experiment Videos

  • Employed multiple linear-regression analysis to adjust for confounding ocular and non-ocular variables, including glaucoma therapy.
  • Compared assay results with values obtained from a cortisol radioimmunoassay.

    • Main Results:

    • Open-angle glaucoma patients demonstrated significantly higher plasma glucocorticoid activities compared to normal subjects.
    • In glaucoma patients, a substantial portion of biologic glucocorticoid activity could not be attributed to cortisol alone.
    • Normal and ocular hypertensive groups showed plasma glucocorticoid activity primarily accounted for by cortisol.

    Conclusions:

    • Non-cortisol glucocorticoids appear to be responsible for elevated biologic plasma glucocorticoid activity in open-angle glaucoma.
    • These findings suggest a potential disturbance in the hypothalamic-pituitary-adrenal axis in open-angle glaucoma patients.
    • Open-angle glaucoma may be associated with increased plasma levels of both cortisol and other non-cortisol glucocorticoids.