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Microfluidic Mixers for Studying Protein Folding

Microfluidic Mixers for Studying Protein Folding

Published on: April 10, 2012

Passive Microfluidic device for Sub Millisecond Mixing.

Zonghuan Lu¹, Jay McMahon, Hisham Mohamed

¹Center for Integrated Electronics, Rensselaer Polytechnic Institute, Troy, NY 12180.

Sensors and Actuators. B, Chemical

|February 18, 2010

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This study introduces a novel microfluidic mixer for submillisecond fluid mixing. The device achieves efficient mixing of biological macromolecules, crucial for time-resolved dynamic studies.

Area of Science:

Microfluidics
Biophysics
Chemical Engineering

Background:

Achieving rapid and efficient mixing is critical for time-resolved studies in macromolecular dynamics.
Conventional mixing techniques often lack the speed and precision required for submillisecond processes.

Purpose of the Study:

To investigate a novel microfluidic mixing device designed for submillisecond mixing.
To evaluate the mixing efficiency of the device using both simulations and experimental methods.

Main Methods:

Utilized three-dimensional fluidic simulations to model mixing efficiency.
Constructed physical microfluidic devices using conventional microfabrication.
Experimentally validated mixing performance using fluorescein dye and nanoparticles.

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Analyzing Mixing Inhomogeneity in a Microfluidic Device by Microscale Schlieren Technique

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Published on: June 12, 2015

Main Results:

Simulations predicted thorough mixing at flow rates as low as 6 µL/s, with mean residence times under 0.5 ms.
Experimental results showed high mixing indices (96% for dye, 98% for nanoparticles) at 6 µL/s.
Experimental data closely matched simulation predictions, confirming device efficacy.

Conclusions:

The novel microfluidic mixer effectively achieves submillisecond mixing.
The device shows significant potential for time-resolved studies of biological macromolecular dynamics.