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Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Related Experiment Video

Updated: Jun 16, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Vitamin D, the immune system and asthma.

Nancy E Lange¹, Augusto Litonjua, Catherine M Hawrylowicz

¹Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham & Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA Tel.: +1 617 525 0874 nlange@partners.org.

Expert Review of Clinical Immunology

|February 18, 2010

Summary

Vitamin D is crucial for immune function and may impact asthma development. Research suggests a link between vitamin D levels and immune-mediated diseases, infections, and cancer.

More Related Videos

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Related Experiment Videos

Last Updated: Jun 16, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

Immunology
Endocrinology
Respiratory Medicine

Background:

Vitamin D is well-known for its role in bone metabolism and calcium homeostasis.
Emerging research highlights vitamin D's critical function in regulating both innate and cell-mediated immunity.
Vitamin D deficiency is linked to increased susceptibility to infections, cancer, and immune-mediated diseases.

Purpose of the Study:

To explore the emerging evidence linking vitamin D to immune system regulation.
To investigate the potential role of vitamin D in the development and progression of asthma.
To highlight the implications of understanding vitamin D's function in lung development and immunity for asthma prevention and treatment.

Main Methods:

Review of existing scientific literature on vitamin D, immunity, and respiratory health.
Analysis of studies investigating vitamin D levels in patients with immune-mediated conditions and asthma.
Synthesis of data on vitamin D's impact on immune cell function and lung development.

Main Results:

Vitamin D plays a significant role in modulating immune responses.
Vitamin D deficiency is associated with a higher risk of infections and certain cancers.
Preliminary data suggests a correlation between low vitamin D levels and asthma prevalence or severity.

Conclusions:

Vitamin D is a key regulator of the immune system with potential implications beyond bone health.
Further research into the specific mechanisms of vitamin D in lung immunity is warranted.
Elucidating vitamin D's role may offer novel therapeutic strategies for asthma prevention and management.