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Patch testing with dermatophagoides and its correlation with chronic eczema and atopic dermatitis
Chetna Kapur1, Shrutakirthi D Shenoi, Smitha S Prabhu
1Department of Skin and STD, Kasturba Medical College, Manipal, India.
Indian Journal of Dermatology
|February 18, 2010
Summary
Patch testing for Dermatophagoides pteronyssinus (DP) mix is significant in identifying allergies in patients with chronic eczema and atopic dermatitis. This method aids in detecting delayed-type hypersensitivity to house dust mites, crucial for managing these skin conditions.
Area of Science:
- Dermatology
- Allergology
- Clinical Immunology
Background:
- Chronic eczema and atopic dermatitis are prevalent in India.
- House dust mites (Dermatophagoides) are linked to atopic dermatitis, asthma, and rhinitis.
- Patch testing with Dermatophagoides pteronyssinus (DP) is recognized for diagnosing contact sensitization in chronic dermatitis.
Purpose of the Study:
- To investigate the clinical features of patients with chronic dermatitis and atopic dermatitis who tested positive for DP mix.
- To assess the prevalence and characteristics of DP mix positivity in dermatological outpatients.
Main Methods:
- Eighty-six dermatology outpatients with diagnosed atopic dermatitis or chronic eczema were selected.
- Patients underwent patch testing using a standard series and a DP mix.
- Inclusion and exclusion criteria were clearly defined for patient selection.
Main Results:
- 58% (50 out of 86) of patients tested positive for DP mix.
- Among DP mix-positive patients, 84% had chronic dermatitis, with 74% showing involvement of exposed areas.
- Atopic dermatitis was observed in 38% of the DP mix-positive group, compared to 17% in the DP mix-negative group.
Conclusions:
- Dermatophagoides mix positivity showed a statistically significant association with both chronic eczema and atopic dermatitis.
- Patch testing is a valuable diagnostic tool for identifying delayed-type allergies to house dust mites.
- These findings highlight the importance of house dust mite allergy in the pathogenesis of chronic skin conditions.
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