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Related Experiment Video

Updated: Jun 16, 2026

Basophil Activation Test for Allergy Diagnosis

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Published on: May 31, 2021

Chronic autoimmune urticaria: where we stand?

C L Goh¹, K T Tan

¹Department of Dermatology, National Skin Center, Singapore.

Indian Journal of Dermatology

|February 18, 2010

Summary

This summary is machine-generated.

Chronic autoimmune urticaria, often triggered by autoantibodies, affects about 42% of patients. Diagnosis involves tests like the autologous serum skin test, with treatments including antihistamines and immunomodulators.

Keywords:

Chronic autoimmune urticaria chronic urticaria urticaria

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Area of Science:

Immunology
Dermatology
Allergy

Background:

Chronic idiopathic urticaria (CIU) has an autoimmune basis in 30-40% of cases.
Chronic autoimmune urticaria (CAU) is mediated by autoantibodies (anti-FcepsilonRI or anti-IgE) causing mast cell activation and mediator release.
Complement activation via C5a plays a role in mast cell and inflammatory cell recruitment in CAU.

Purpose of the Study:

To review the pathophysiology, diagnosis, and treatment of chronic autoimmune urticaria.
To highlight the association between CAU and autoimmune thyroid disease.
To present the prevalence of CAU and associated thyroid autoimmunity in Singapore.

Main Methods:

Literature review of autoimmune urticaria.
Discussion of diagnostic tools including autologous serum skin test and basophil histamine release assay.
Overview of treatment strategies for CAU.

Main Results:

CAU prevalence in Singapore mirrors Western data (approx. 42%).
Thyroid autoimmunity is frequently observed in patients with CIU (22.5% in Singapore).
Autologous serum skin test shows 70% sensitivity and 80% specificity for CAU.

Conclusions:

Chronic autoimmune urticaria is a significant subtype of chronic urticaria with distinct autoimmune mechanisms.
Early identification and management of CAU, considering potential thyroid comorbidity, are crucial.
Treatment approaches range from antihistamines to immunomodulators for refractory cases.