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Related Concept Videos

Role of Amygdala in Memory01:16

Role of Amygdala in Memory

The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
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Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
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Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

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Related Experiment Video

Updated: Jun 16, 2026

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons
10:53

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons

Published on: September 15, 2014

A simple role for BDNF in learning and memory?

Carla Cunha1, Riccardo Brambilla, Kerrie L Thomas

  • 1Department of Biotechnology and Biosciences, University of Milano-Bicocca Milan, Italy.

Frontiers in Molecular Neuroscience
|February 18, 2010
PubMed
Summary
This summary is machine-generated.

Brain-derived neurotrophic factor (BDNF) is crucial for neuron survival and function. Understanding BDNF

Keywords:
BDNFbehaviourcell signallinglearning and memorysynaptic plasticitysynaptogenesis

More Related Videos

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
13:46

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

Published on: July 11, 2020

Related Experiment Videos

Last Updated: Jun 16, 2026

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons
10:53

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons

Published on: September 15, 2014

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
13:46

An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons

Published on: July 11, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology

Background:

  • Brain-derived neurotrophic factor (BDNF) is a secreted neurotrophin vital for neuronal differentiation and survival in the central nervous system (CNS).
  • BDNF also plays a key role in regulating synaptogenesis and synaptic plasticity, which are fundamental to learning and memory in adult CNS.

Purpose of the Study:

  • To review intracellular signaling pathways activated by BDNF.
  • To discuss the role of BDNF in long-term synaptic plasticity, memory formation, and synaptogenesis.
  • To explore how BDNF maturation, localization, and regulation of synapses impact synaptic plasticity and memory.

Main Methods:

  • Literature review of existing research on BDNF.
  • Analysis of intracellular signaling pathways activated by BDNF.
  • Examination of BDNF's role in synaptic plasticity and memory formation.

Main Results:

  • BDNF influences neuronal differentiation, survival, synaptogenesis, and synaptic plasticity.
  • Multiple intracellular signaling pathways are activated by BDNF.
  • BDNF's effects on synaptic plasticity and memory can be complex and potentially conflicting due to factors like maturation and localization.

Conclusions:

  • Precise understanding of BDNF's mechanisms in cognitive functions is limited.
  • Further research is needed to elucidate BDNF's role in higher cognitive functions and complex behaviors.
  • A deeper knowledge of BDNF mechanisms is essential for developing effective BDNF-based therapeutics for CNS disorders.