Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flow Cytometric Assessment of AKT Signaling in Platelet Activation: An Alternative Diagnostic Tool for Small Volumes of Blood.

Hamostaseologie·2020
Same author

Miller-Fisher syndrome after COVID-19: neurochemical markers as an early sign of nervous system involvement.

European journal of neurology·2020
Same author

MR-imaging pattern is not a predictor of occult atrial fibrillation in patients with cryptogenic stroke.

Journal of neurology·2019
Same author

The utility of viscoelastic methods in the prevention and treatment of bleeding and hospital-associated venous thromboembolism in perioperative care: guidance from the SSC of the ISTH.

Journal of thrombosis and haemostasis : JTH·2018
Same author

Use of factor concentrates for the management of perioperative bleeding: reply.

Journal of thrombosis and haemostasis : JTH·2018
Same author

International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy.

Vox sanguinis·2018

Related Experiment Video

Updated: Jun 16, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Heparin-induced thrombocytopenia.

A Greinacher1, K Althaus, K Krauel

  • 1Institut für Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt Universität Greifswald. greinach@uni-greifswald.de

Hamostaseologie
|February 18, 2010
PubMed
Summary

Heparin-induced thrombocytopenia (HIT) is an antibody-mediated drug reaction increasing thrombosis risk. Understanding HIT immunobiology may reveal how host defenses trigger autoimmunity.

More Related Videos

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
05:35

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

Related Experiment Videos

Last Updated: Jun 16, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
11:17

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
05:35

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

Area of Science:

  • Immunology
  • Pharmacology
  • Hematology

Background:

  • Heparin-induced thrombocytopenia (HIT) is a critical adverse drug reaction during heparin therapy.
  • It involves antibodies targeting platelet factor 4 (PF4)/heparin complexes, leading to increased thrombotic risk.
  • Current diagnostic tests for HIT possess high negative but moderate positive predictive value.

Purpose of the Study:

  • To elucidate the immunobiology of HIT.
  • To explore the relationship between HIT and host defense mechanisms.
  • To understand why immune responses can lead to autoimmunity.

Main Methods:

  • Review of current literature on HIT pathogenesis and immunobiology.
  • Analysis of antibody-antigen interactions in HIT.
  • Comparison of HIT immunobiology with microbial defense mechanisms.

Main Results:

  • HIT is mediated by platelet-activating antibodies against PF4/heparin complexes.
  • Not all PF4/heparin-reactive antibodies induce HIT, impacting diagnostic accuracy.
  • HIT's immunobiology resembles immunity against repetitive antigens found in microbial defense.

Conclusions:

  • Clinical management of HIT necessitates heparin cessation and alternative anticoagulation.
  • Understanding HIT's autoimmune mimicry offers insights into self-defense mechanisms triggering autoimmunity.
  • Further research into HIT immunobiology can clarify autoimmune triggers.