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Do 5-fluorouracil therapies alter CYP2C19 metaboliser status?

N A Helsby1, W Y Lo, P Thompson

  • 1Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. n.helsby@auckland.ac.nz

Cancer Chemotherapy and Pharmacology
|February 18, 2010
PubMed
Summary

5-fluorouracil (FU) treatment altered a patient's CYP2C19 metaboliser status, leading to decreased enzyme activity and a shift from extensive to poor metaboliser. This change coincided with the development of hand and foot syndrome.

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