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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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Updated: Jun 16, 2026

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
06:46

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Published on: July 25, 2025

Needle-based blocks for the 21st century ophthalmology.

Chandra M Kumar1

  • 1The James Cook University Hospital, Middlesbrough, UK. chandra.kumar@stees.nhs.uk

Acta Ophthalmologica
|February 19, 2010
PubMed
Summary

Modern needle orbital blocks offer safer anesthesia for ophthalmic surgery. These techniques provide effective anesthesia and lid akinesia, improving patient outcomes compared to older methods.

Area of Science:

  • Ophthalmology
  • Anesthesiology
  • Medical History

Background:

  • Needle-based orbital blocks have a long history in ophthalmic anesthesia.
  • Early techniques like the Atkinson retrobulbar block were developed in the early 20th century.

Observation:

  • Classical retrobulbar blocks, using long needles, have raised safety concerns for modern ophthalmic surgery.
  • Alternative techniques with shorter needles and specific injection sites can achieve satisfactory anesthesia and akinesia.

Findings:

  • Modern needle orbital blocks have evolved for enhanced safety and efficacy.
  • Shorter needles and adjusted anesthetic volumes in the inferotemporal quadrant yield good results.
  • Current methods provide lid akinesia without requiring a separate facial nerve injection.

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Implications:

  • These advancements contribute to safer anesthetic practices in contemporary ophthalmic procedures.
  • Improved techniques enhance patient safety and surgical outcomes.
  • The evolution of orbital blocks reflects progress in anesthetic delivery for eye surgery.