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Updated: Jun 16, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
Chronic urticaria of neonatal onset: a potential sign of autoinflammation
Sam Mehr1, Kristi J Jones, Davinder Singh-Grewal
1Departments of Allergy and Immunology, The Children's Hospital at Westmead, University of Sydney, Sydney, New South Wales, Australia.
Abstract:
We present a 6 year old boy with chronic urticaria of neonatal onset associated in childhood with features of neurological and joint inflammation. Genetic analysis confirmed the diagnosis of neonatal onset multi-inflammatory disorder (NOMID). Daily subcutaneous anti-IL-1 receptor antagonist therapy resulted in a dramatic and sustained amelioration of systemic inflammation. NOMID must be considered in any child with chronic urticaria of neonatal/infantile onset, particularly if associated with joint and/or neurological inflammation.
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