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Sodium fluoride in otosclerosis treatment: review
A S Cruise1, A Singh, R E Quiney
1Department of Otolaryngology, Royal Free Hospital, London, UK. mr.andrew.cruise@gmail.com
Objectives:
To review the current literature on the use of sodium fluoride in the treatment of otosclerosis.
Design:
A literature review was conducted, searching the Medline and PubMed database from 1966 to 2009, using the terms 'otosclerosis' and 'fluoride'. Article abstracts were reviewed and relevant full articles acquired.
Results:
There has been only one double-blind, placebo-controlled trial of the use of sodium fluoride in otosclerosis patients, and this found a reduced incidence of deterioration in hearing after two years in the treatment group. Several case-control series have described a hearing benefit in the sodium fluoride treated group. Treatment doses vary greatly, and there is no evidence regarding the optimum duration of treatment.
Conclusions:
There is low quality evidence suggesting that sodium fluoride may be of benefit to preserve hearing and reduce vestibular symptoms in patients with otosclerosis.
