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Updated: Jun 16, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Prognostic value of exercise echocardiography in patients with atrial fibrillation
Alberto Bouzas-Mosquera1, Jesús Peteiro, Francisco J Broullón
1Department of Cardiology, Hospital Universitario A Coruña, As Xubias, 84, 15006 A Coruña, Spain. aboumos@canalejo.org
Insights
Exercise echocardiography (ExEcho) effectively predicts cardiac events in patients with atrial fibrillation (AF). This non-invasive test identifies ischaemia, aiding risk stratification for coronary artery disease (CAD) in this challenging population.
Area of Science:
- Cardiology
- Diagnostic Imaging
- Clinical Medicine
Background:
- Non-invasive imaging for coronary artery disease (CAD) faces challenges in patients with atrial fibrillation (AF).
- Exercise echocardiography (ExEcho) is a well-established prognostic tool, but its utility in AF patients is not well-defined.
Purpose of the Study:
- To evaluate the prognostic value of ExEcho in patients with AF undergoing testing for CAD.
- To determine if ExEcho can independently predict hard cardiac events in this specific patient group.
Main Methods:
- Retrospective analysis of 8095 patients referred for ExEcho, identifying 419 with AF.
- Ischaemia defined by exercise-induced wall motion abnormalities.
- Primary endpoint: hard cardiac events (cardiac death or non-fatal myocardial infarction).
Main Results:
- Ischaemia was detected in 22% of AF patients.
- A significantly higher 5-year hard cardiac event rate (37.3%) was observed in patients with ischaemia compared to those without (14.5%).
- ExEcho-identified ischaemia independently predicted hard cardiac events (HR 1.99, P=0.03) and provided incremental prognostic value.
Conclusions:
- Exercise echocardiography is a valuable tool for risk stratification in patients with AF and suspected CAD.
- ExEcho offers significant prognostic information for predicting hard cardiac events in this population.
Aims:
Non-invasive imaging techniques for the detection of coronary artery disease (CAD) may have technical problems in patients with atrial fibrillation (AF). Although the prognostic value of exercise echocardiography (ExEcho) has been well established in several subgroups of patients, it has not yet been specifically evaluated in these patients.
Methods And Results:
From a population of 8095 patients with known or suspected CAD referred for ExEcho, 419 had AF at the time of the tests. Ischaemia was defined as the development of new or worsening wall motion abnormalities with exercise. Endpoints were hard cardiac events (i.e. cardiac death or non-fatal myocardial infarction). Mean age was 68.4 +/- 8.5 years, and 256 patients (61.1%) were men. Ischaemia was detected in 92 patients (22%). Over a mean follow-up of 3.10 +/- 2.98 years, 59 hard cardiac events occurred. The 5-year hard cardiac event rate was 37.3% in patients with ischaemia, when compared with 14.5% in patients without ischaemia (P < 0.001). In multivariate analysis, ischaemia on ExEcho remained an independent predictor of hard cardiac events (hazard ratio 1.99, 95% confidence interval 1.06-3.74, P = 0.03), and also provided incremental value over clinical, resting echocardiographic and treadmill exercise data for the prediction of hard cardiac events (P = 0.04).
Conclusion:
ExEcho provides significant prognostic information for predicting hard cardiac events in patients with AF.
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