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Updated: Jun 16, 2026

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Published on: February 10, 2023
The syndrome of inappropriate antidiuretic hormone: prevalence, causes and consequences
1Academic Department of Endocrinology, Beaumont Hospital and RCSI Medical School, Dublin, Ireland.
Abstract:
Hyponatraemia is the commonest electrolyte abnormality found in hospital inpatients, and is associated with a greatly increased morbidity and mortality. The syndrome of inappropriate antidiuretic hormone (SIADH) is the most frequent cause of hyponatraemia in hospital inpatients. SIADH is the clinical and biochemical manifestation of a wide range of disease processes, and every case warrants investigation of the underlying cause. In this review, we will examine the prevalence, pathophysiology, clinical characteristics and clinical consequences of hyponatraemia due to SIADH.
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