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Lysine requirement in parenterally fed postsurgical human neonates
Karen P Chapman1, Glenda Courtney-Martin, Aideen M Moore
1Research Institute, The Hospital for Sick Children, Toronto, Canada.
The American Journal of Clinical Nutrition
|February 19, 2010
Summary
The recommended parenteral lysine requirement for neonates is 104.9 mg/kg/day, significantly lower than current parenteral nutrition solutions. This finding impacts infant nutrition and clinical practice.
Area of Science:
- Nutritional biochemistry
- Neonatal medicine
- Metabolic research
Background:
- Parenteral nutrition (PN) is crucial for neonates unable to receive enteral feeding.
- The specific lysine requirements for neonates on PN have not been experimentally established.
- Accurate amino acid requirements are vital for optimal growth and metabolic outcomes in infants.
Purpose of the Study:
- To determine the precise parenteral lysine requirement in human neonates.
- To utilize the indicator amino acid oxidation technique for accurate assessment.
- To establish evidence-based recommendations for lysine content in neonatal PN.
Main Methods:
- Employed the indicator amino acid oxidation technique using l-[1-(13)C] phenylalanine.
- Administered varying lysine intakes (50-260 mg/kg/day) to 11 postsurgical neonates.
- Analyzed breath and urine samples to measure isotope enrichment and amino acid oxidation rates.
Main Results:
- The mean lysine requirement was determined to be 104.9 mg/kg/day (95% CI: 89.1-120.6).
- Lysine intake did not affect phenylalanine flux, indicating specificity of the measurement.
- This recommended intake is substantially lower than typical commercial PN formulations.
Conclusions:
- A mean parenteral lysine requirement of 104.9 mg/kg/day is recommended for postsurgical neonates receiving PN.
- Current commercial PN solutions may provide 32-43% more lysine than necessary.
- Findings suggest a need to revise current neonatal PN formulations for optimal lysine content.
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