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Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
Working Memory01:24

Working Memory

Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this information.
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or playing an...
Long-Term Memory01:18

Long-Term Memory

Long-term memory is a relatively permanent type of memory, capable of storing vast amounts of information over extended periods. Its storage capacity is generally considered unlimited.
Long-term memory can be categorized into two primary types: explicit and implicit memory. Explicit memory, also known as declarative memory, involves the conscious recollection of information that we deliberately try to remember, recall, and articulate. This type of memory encompasses specific facts, events, and...
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

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Related Experiment Video

Updated: Jun 16, 2026

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Hippocampal gamma oscillations increase with memory load.

Marieke K van Vugt1, Andreas Schulze-Bonhage, Brian Litt

  • 1Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08540, USA. mkvan@princeton.edu

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|February 19, 2010
PubMed
Summary
This summary is machine-generated.

This study shows that gamma oscillations in the hippocampus increase with memory load during working memory tasks involving letters and faces. This provides direct evidence for the hippocampus's role in working memory.

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Last Updated: Jun 16, 2026

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

Generation of Local CA1 γ Oscillations by Tetanic Stimulation
08:02

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Published on: August 14, 2015

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Memory Research

Background:

  • The hippocampus is vital for episodic memory but its role in working memory remains debated.
  • Understanding hippocampal and neocortical contributions to working memory is essential.

Purpose of the Study:

  • To investigate the role of the hippocampus and neocortex in working memory.
  • To examine electrocorticographic activity during working memory tasks.

Main Methods:

  • Electrocorticographic activity was recorded from widespread cortical and subcortical sites in 20 neurosurgical patients.
  • Patients performed working memory tasks involving letters and faces.

Main Results:

  • Significant increases in 48-90 Hz gamma oscillatory power were observed with increasing memory load.
  • These gamma increases were primarily localized to the hippocampus and medial temporal lobe.
  • This pattern was consistent for both letter and face stimuli.

Conclusions:

  • Gamma oscillatory activity is implicated in the maintenance of information in working memory.
  • This study offers the first direct evidence of hippocampal gamma oscillation modulation during human working memory tasks.