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Local anesthetics inhibit Ca-ATPase in masticatory muscles

G A Sánchez1, D Takara, G L Alonso

  • 1Biophysics Department, Faculty of Dentistry, University of Buenos Aires, MT de Alvear 2142, C1122AAH, Buenos Aires, Argentina. gabriel@odon.uba.ar

Journal of Dental Research
|February 19, 2010
PubMed

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Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
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