Related Experiment Video
Updated: Jun 16, 2026
07:17
Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
Published on: August 23, 2024
HLA-DR association in papillary thyroid carcinoma
Mahsa M Amoli1, Nasrin Yazdani, Parvin Amiri
1Endocrinology and metabolism research centre, Tehran university of medical sciences, Tehran, Iran. mahsa_amoli@hotmail.com
Disease Markers
|February 19, 2010
Summary
The Human Leukocyte Antigen (HLA)-DRB1*04 allele is associated with an increased risk of papillary thyroid carcinoma in the Iranian population. This finding supports previous research linking HLA-DRB1 to differentiated thyroid cancers.
Area of Science:
- Immunogenetics
- Oncology
Background:
- Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy.
- Human Leukocyte Antigens (HLA) genes are implicated in cancer susceptibility.
- Previous studies suggest certain HLA alleles influence thyroid cancer risk in diverse populations.
Purpose of the Study:
- To investigate the association between HLA-DR alleles and papillary thyroid carcinoma in an Iranian cohort.
- To identify potential predisposing or protective HLA-DR alleles for PTC in this specific ethnic group.
Main Methods:
- Case-control study design.
- Participant recruitment included 70 PTC patients and 180 healthy controls.
- HLA-DR antigen frequencies were determined using Polymerase Chain Reaction - Sequence Specific Primers (PCR-SSP).
Main Results:
- The frequency of the HLA-DRB1*04 allele was significantly higher in PTC patients compared to healthy controls (P=0.02).
- An odds ratio of 1.9 (95% CI: 1.04-3.57) indicated an increased risk associated with HLA-DRB1*04.
Conclusions:
- The HLA-DRB1*04 allele is identified as a predisposing factor for papillary thyroid carcinoma in the Iranian population.
- These findings corroborate prior research on the role of HLA-DRB1 in differentiated thyroid carcinomas across different ethnicities.
Related Concept Videos
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
01:27Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
02:39lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...