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PSA decrease with fulvestrant acetate in a hormone-resistant metastatic prostate cancer patient
Joan M Gasent Blesa1, Vicente Alberola Candel
1Department of Medical Oncology, Hospital de Dènia, Alacant, Spain. joanmagasent@telefonica.net
Background:
Androgen-independent prostate cancer (AIPCA) is a difficult disease to treat. Fulvestrant has shown activity inhibiting estrogen receptor dimerization, and the androgen receptor has been shown to stimulate growth in prostate cancer cell lines.
Case Report:
A 79-year-old metastatic prostate cancer patient with AIPCA was treated with fulvestrant acetate with a loading dose strategy. Without recording any significant side effects, the prostate-specific antigen (PSA) level decreased from 154 ng/ml to 0.45 ng/ml 8 weeks after the first treatment administration.
Conclusion:
Fulvestrant was able to reduce the PSA level in this AIPC patient without any toxicity.
