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Updated: Jun 16, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Sputum smear microscopy in DOTS: Are three samples necessary? An analysis and its implications in tuberculosis
1Department of Tuberculosis and Respiratory Diseases, Yenepoya Medical College, Deralakatte, Mangalore - 575 018, Karnataka, India.
Objectives:
To assess relevance of spot morning spot (SMS) method of smear microscopy in tuberculosis control by directly observed treatment short course (DOTS).
Materials And Methods:
Screening of smear microscopy results of 546 cases of pulmonary tuberculosis at our DOTS centre.
Results:
Among 546 cases, 82% had all three samples positive for AFB, 98% had either morning sample or spot and morning sample positive. 2% had second spot sample positive.
Conclusion:
Examination of third sample, especially second spot sample, does not add significantly to the diagnostic yield. Examination of one spot and early morning samples were able to correctly diagnose 98% cases. This has strong implications in DOTS strategies.
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