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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...

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Related Experiment Video

Updated: Jun 16, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Targeting p53 for Novel Anticancer Therapy.

Zhen Wang1, Yi Sun

  • 1Institute of Medicinal Biotechnology, PUMC&CAMS, Beijing, People's Republic of China, 100050.

Translational Oncology
|February 19, 2010
PubMed
Summary
This summary is machine-generated.

Targeting the p53 tumor suppressor protein offers a promising strategy for cancer therapy. Researchers are developing drugs to activate p53 in cancer cells or protect normal cells during treatment.

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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Last Updated: Jun 16, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Carcinogenesis involves genetic mutations, with p53 tumor suppressor inactivation occurring in 50% of human cancers.
  • p53 is crucial for tumor suppression, inducing apoptosis and inhibiting angiogenesis, and sensitizing cells to chemoradiation.

Purpose of the Study:

  • To review current strategies for targeting p53 and its regulators in anticancer drug discovery.
  • To explore therapeutic approaches aimed at activating p53 in cancer cells or protecting normal cells.

Main Methods:

  • Focus on mechanism-driven drug discovery targeting p53 pathways.
  • Categorization of p53 modulators based on their therapeutic application (activation, reactivation, inhibition).

Main Results:

  • Compounds activating wild-type p53 can treat cancers with functional p53.
  • Strategies for reactivating mutant p53 or utilizing synthetic lethality offer selective treatment for mutant p53 cancers.
  • Inhibitors of wild-type p53 can mitigate normal cell toxicity during chemoradiation.

Conclusions:

  • Targeting p53 modulators holds potential to revolutionize cancer therapy.
  • Development of p53-targeting drugs, alone or with chemoradiation, could significantly benefit cancer patients.