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Related Concept Videos

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Drug Therapy

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Related Experiment Video

Updated: Jun 16, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Pharmaceutical interventions for emotionalism after stroke.

Maree L Hackett1, Michelle Yang, Craig S Anderson

  • 1Department of Neurological and Mental Health, The George Institute for International Health, PO Box M201, Missenden Road, Sydney, NSW, Australia, 2050.

The Cochrane Database of Systematic Reviews
|February 19, 2010
PubMed
Summary
This summary is machine-generated.

Antidepressants may help reduce emotional outbursts like crying and laughing after a stroke. However, more research is needed due to study limitations.

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Last Updated: Jun 16, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint
06:45

Effect of Yi-Nao-Jie-Yu Prescription on Post-Stroke Depression in Rats using Middle Cerebral Artery Occlusion Combined with Behavioral Restraint

Published on: January 9, 2026

Area of Science:

  • Neurology
  • Psychiatry
  • Clinical Trials

Background:

  • Emotionalism, characterized by abnormal crying or laughing, can occur after a stroke.
  • Antidepressant medications are being investigated as a potential treatment for post-stroke emotionalism.

Purpose of the Study:

  • To evaluate the effectiveness of pharmaceutical treatments in reducing emotional displays in stroke survivors with emotionalism.

Main Methods:

  • Systematic review and meta-analysis of randomized and quasi-randomized controlled trials.
  • Searched multiple databases including MEDLINE, EMBASE, PsycINFO, and Cochrane Register.
  • Included trials comparing psychotropic medication to placebo in stroke patients with emotional lability.

Main Results:

  • Seven trials with 239 participants were included; data from five trials (213 participants) were analyzed.
  • Five trials indicated significant reductions in emotionalism frequency and severity.
  • Wide confidence intervals suggest potential for small positive or negative effects; adverse events were similar between groups.

Conclusions:

  • Antidepressants appear to reduce the frequency and severity of emotional outbursts following stroke.
  • The observed effects do not appear specific to a particular drug or drug class.
  • Methodological limitations in the included studies necessitate further high-quality research for definitive treatment recommendations.