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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Circulating human group A rotavirus genotypes in Malaysia
H Zuridah1, C D Kirkwood, N Bogdanovic-Sakran
1Faculty of Health Sciences, Universiti Teknologi MARA, Jalan Othman, Petaling, Jaya, Selangor, Malaysia. drzuridah@salam.uitm.edu.my
Journal of Medical Virology
|February 19, 2010
Summary
Rotavirus genotype surveillance in Malaysia revealed a significant shift. The G1P[8] strain dominated in 1996, but by 2007, G9P[8] became the most prevalent rotavirus strain in children with diarrhea.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Rotavirus is a leading cause of severe diarrheal disease in infants and young children globally.
- Genotypic diversity of rotavirus strains influences disease epidemiology and vaccine effectiveness.
- Understanding temporal genotype distribution is crucial for public health interventions and vaccine strain selection.
Purpose of the Study:
- To investigate the temporal changes in rotavirus G and P genotypes circulating in Malaysia.
- To compare rotavirus genotype prevalence between 1996 and 2007 in hospitalized children.
Main Methods:
- Retrospective analysis of rotavirus strains from children with diarrhea in Peninsular Malaysia.
- Samples collected in 1996 (n=93) and 2007 (n=12) were analyzed.
- Hemi-nested reverse transcription-polymerase chain reaction (RT-PCR) assay was used for G and P genotyping.
Main Results:
- In 1996, the G1P[8] rotavirus strain was predominant, accounting for 81% of samples.
- In 2007, a significant shift was observed, with G9P[8] becoming the dominant strain (42%).
- No G9 genotype strains were detected in the 1996 samples, while G1 strains were prevalent in the remaining 2007 samples.
Conclusions:
- A notable temporal shift in rotavirus G genotypes occurred in Malaysia between 1996 and 2007.
- The emergence and dominance of the G9P[8] strain highlight the dynamic nature of rotavirus epidemiology.
- Continuous rotavirus genotype surveillance is essential for monitoring epidemiological trends and informing public health strategies.
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