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Updated: Jun 16, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
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Published on: January 28, 2019

Circulating human group A rotavirus genotypes in Malaysia.

H Zuridah1, C D Kirkwood, N Bogdanovic-Sakran

  • 1Faculty of Health Sciences, Universiti Teknologi MARA, Jalan Othman, Petaling, Jaya, Selangor, Malaysia. drzuridah@salam.uitm.edu.my

Journal of Medical Virology
|February 19, 2010
PubMed
Summary

Rotavirus genotype surveillance in Malaysia revealed a significant shift. The G1P[8] strain dominated in 1996, but by 2007, G9P[8] became the most prevalent rotavirus strain in children with diarrhea.

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Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Rotavirus is a leading cause of severe diarrheal disease in infants and young children globally.
  • Genotypic diversity of rotavirus strains influences disease epidemiology and vaccine effectiveness.
  • Understanding temporal genotype distribution is crucial for public health interventions and vaccine strain selection.

Purpose of the Study:

  • To investigate the temporal changes in rotavirus G and P genotypes circulating in Malaysia.
  • To compare rotavirus genotype prevalence between 1996 and 2007 in hospitalized children.

Main Methods:

  • Retrospective analysis of rotavirus strains from children with diarrhea in Peninsular Malaysia.
  • Samples collected in 1996 (n=93) and 2007 (n=12) were analyzed.
  • Hemi-nested reverse transcription-polymerase chain reaction (RT-PCR) assay was used for G and P genotyping.

Main Results:

  • In 1996, the G1P[8] rotavirus strain was predominant, accounting for 81% of samples.
  • In 2007, a significant shift was observed, with G9P[8] becoming the dominant strain (42%).
  • No G9 genotype strains were detected in the 1996 samples, while G1 strains were prevalent in the remaining 2007 samples.

Conclusions:

  • A notable temporal shift in rotavirus G genotypes occurred in Malaysia between 1996 and 2007.
  • The emergence and dominance of the G9P[8] strain highlight the dynamic nature of rotavirus epidemiology.
  • Continuous rotavirus genotype surveillance is essential for monitoring epidemiological trends and informing public health strategies.