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Reduced rate of side effects associated with separate administration of MMR and DTaP-Hib-IPV vaccinations

Elena Shneyer1, Avshalom Strulov, Yaakov Rosenfeld

  • 1School of Public Health, Haifa University, Haifa, Israel.

The Israel Medical Association Journal : IMAJ
|February 20, 2010
PubMed

Insights

Separating infant vaccinations, such as measles-mumps-rubella (MMR) and diphtheria-tetanus-acellular pertussis-Haemophilus influenzae type b-poliomyelitis (DTaP-Hib-IPV), may reduce adverse effects. This study found lower side effect rates when these vaccines were administered separately.

Area of Science:

  • Pediatrics
  • Immunology
  • Public Health

Background:

  • The Israeli immunization schedule recommends concomitant administration of MMR and DTaP-Hib-IPV vaccines for 1-year-olds.
  • A significant proportion of infants in Israel receive these vaccinations separately.
  • Clinical observations suggest a lower incidence of side effects with separate vaccination schedules.

Purpose of the Study:

  • To investigate and validate the observed association between separate vaccination administration and reduced adverse effects in infants.
  • To determine if the lower rate of side effects is a consistent finding or an isolated observation.

Main Methods:

  • A nested prospective follow-up study was conducted in an Israeli primary care clinic.
  • The study involved 191 mother-infant pairs born between 2004 and 2005.
  • Mothers were interviewed via telephone two weeks post-vaccination to assess adverse effects.

Main Results:

  • Infants receiving separate vaccinations experienced a significantly lower rate of adverse effects compared to those receiving combined injections (40% vs. 57%).
  • Statistical analysis confirmed a significant difference in adverse event rates between the two vaccination approaches.

Conclusions:

  • The findings suggest that current vaccination policies recommending concomitant injections may warrant reconsideration.
  • Separate administration of infant vaccines could potentially mitigate adverse reactions, improving vaccine tolerance.
Abstract

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