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Integrins

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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Related Experiment Video

Updated: Jun 16, 2026

Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis

Preparing a ⁶⁸Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis

Published on: January 7, 2019

Targeting alphavbeta3 integrin: design and applications of mono- and multifunctional RGD-based peptides and

L Auzzas¹, F Zanardi, L Battistini

¹Istituto di Chimica Biomolecolare del CNR, Traversa La Crucca 3, Li Punti, Sassari I-07100, Italy. luciana.auzzas@icb.cnr.it

Current Medicinal Chemistry

|February 20, 2010

Summary

This review details the development of alpha(v)beta(3) integrin antagonists, focusing on cyclic RGD peptides. It covers their design, synthesis, and diverse biomedical applications in molecular medicine.

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Last Updated: Jun 16, 2026

Preparing a 68Ga-labeled Arginine Glycine Aspartate (RGD)-peptide for Angiogenesis

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Published on: January 7, 2019

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

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Published on: April 27, 2017

Area of Science:

Biochemistry and Molecular Medicine
Drug Discovery and Development

Background:

Integrin receptors play a crucial physio-pathological role, driving significant global scientific interest.
Over twenty years of research have focused on the structural, functional, and biomedical applications of integrin antagonists.

Purpose of the Study:

To summarize efforts in designing, synthesizing, and applying cyclic RGD-containing alpha(v)beta(3) integrin antagonists.
To review both small and macromolecular formats of these antagonists.
To explore RGD-based multifunctional systems in molecular medicine.

Main Methods:

Review of literature on integrin inhibitor design and synthesis.
Analysis of biological and medical applications of monofunctional RGD ligands (monomeric and multimeric).
Evaluation of RGD-based multifunctional systems.

Main Results:

Elucidation of rational design principles for integrin inhibitors.
Demonstration of potent cyclic RGD-containing alpha(v)beta(3) integrin antagonists.
Exploration of diverse biomedical applications, including small and macromolecular formats.

Conclusions:

Cyclic RGD-containing alpha(v)beta(3) integrin antagonists represent a significant advancement in molecular medicine.
These antagonists show promise for various therapeutic applications.
Multifunctional RGD-based systems offer exciting potential for future research.