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Updated: Jun 16, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
[Genetic demyelinating diseases]
Pierre Labauge1, Odile Boespflug-Tanguy
1Département de neurologie, CHU de Montpellier-Nîmes, place du Pr-R.-Debré, 30029 Nîmes cedex, France. labauge@yahoo.fr
Abstract:
Diagnosis of leukodystrophiesin adults is difficult. Diagnosis requires a collaborative approach including clinical,neuroradiological, biochemical, and genetic analyses. Less than thirty percent ofadult-onset leukodystrophies have a precise diagnosis. Improved neuroradiological knowledgeis making it possible to determine MRI (magnetic resonance imaging) phenotypes that point towards specific causes and specific diagnoses. The cavitary leukodystrophies includechildhood ataxia with central nervous system hypomyelination/vanishing white matter(CACH/VWM) syndromeand megalencephalic leukoencephalopathy with subcortical cysts (MLC). Damage tothe posterior spinal cord suggests leukoencephalopathy with damage to the brainstem and cord marrow and is accompanied by elevated lactate (LBSL).
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