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Updated: Jun 16, 2026

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)

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Published on: April 19, 2013

SLC30A8 polymorphism and type 2 diabetes risk: evidence from 27 study groups.

Y L Jing¹, Q M Sun, Y Bi

¹Department of Endocrinology, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD

|February 20, 2010

Summary

This summary is machine-generated.

This meta-analysis confirms that the SLC30A8 (rs13266634) gene variant increases type 2 diabetes risk. The association was significant in both European and Asian populations, highlighting its role in diabetes susceptibility.

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Area of Science:

Genetics
Metabolic Diseases
Epidemiology

Background:

Type 2 diabetes mellitus (T2DM) is a significant global health concern.
Genetic factors play a crucial role in T2DM pathogenesis.
A specific single nucleotide polymorphism (SNP) in the SLC30A8 gene (rs13266634) has been implicated in T2DM risk, but findings are inconsistent.

Purpose of the Study:

To conduct a meta-analysis to clarify the association between the SLC30A8 (rs13266634) polymorphism and T2DM risk.
To provide a more precise estimation of the genetic risk conferred by this SNP.

Main Methods:

A comprehensive literature search was performed in PubMed up to October 2009.
Data from case-control studies were extracted, including odds ratios (ORs) and 95% confidence intervals (CIs).
Analyses were stratified by ethnicity and study design (population-based vs. hospital-based).

Main Results:

The meta-analysis included 27 studies with 42,609 cases and 69,564 controls.
The SLC30A8 (rs13266634) polymorphism was significantly associated with an elevated risk of T2DM in both Europeans (OR=1.15) and Asians (OR=1.15).
No significant difference in risk association was observed between population-based and hospital-based studies.

Conclusions:

The SLC30A8 (rs13266634) C allele is a risk factor for type 2 diabetes.
This genetic risk is particularly pronounced in European and Asian populations.
The findings support the role of SLC30A8 in T2DM susceptibility.