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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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Published on: July 20, 2019

Roles of pleiotrophin in tumor growth and angiogenesis

Evangelia Papadimitriou1, Constantinos Mikelis, Evgenia Lampropoulou

  • 1Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras, Greece. epapad@upatras.gr

European Cytokine Network
|February 20, 2010
PubMed

Insights

Pleiotrophin (PTN) promotes tumor growth and angiogenesis. This review summarizes PTN

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Pleiotrophin (PTN) is a heparin-binding growth factor.
  • PTN exhibits diverse biological activities, notably in the nervous system, tumor growth, and angiogenesis.
  • Growing interest exists in PTN's role in tumor progression, yet receptor and signaling pathway details remain unclear.

Purpose of the Study:

  • To review the involvement of Pleiotrophin (PTN) in tumor growth.
  • To summarize current knowledge on PTN's role in angiogenesis.
  • To elucidate the receptors and signaling pathways associated with PTN in cancer.

Main Methods:

  • Literature review of existing studies on Pleiotrophin (PTN).
  • Analysis of data concerning PTN's function in tumor biology.
  • Synthesis of information on PTN receptors and signaling cascades.

Main Results:

  • Pleiotrophin (PTN) is implicated in promoting tumor growth.
  • PTN plays a significant role in angiogenesis.
  • Key receptors and signaling pathways mediating PTN's effects are being identified.

Conclusions:

  • Pleiotrophin (PTN) is a critical factor in tumor growth and angiogenesis.
  • Understanding PTN's receptors and pathways is essential for cancer research.
  • Further investigation into PTN signaling may reveal therapeutic targets.

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