Mast cell contribution to tumor angiogenesis: a clinical approach

Mast cells (MCs) are tissue leukocytes that are distributed throughout the major organs of the body. They are an important local source of preformed and newly synthesized angiogenic molecules. MCs have been linked both to inflammatory and tumor angiogenesis. Indeed, numerous solid tumors and hematological malignancies present MC-rich infiltrates, which are believed to contribute to the formation of a new vascular supply. In addition, angiogenesis and MC density have been shown to increase simultaneously with the pathological progression in many of such tumors. This review will focus on the angiogenic potential of MCs in human solid and hematological tumors.