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Related Experiment Videos

Bladder wall abnormalities in myelodysplastic bladders: a computer assisted morphometric analysis.

E Shapiro1, M J Becich, E Perlman

  • 1Department of Urology, Medical College of Wisconsin, Milwaukee.

The Journal of Urology
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

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Myelodysplastic bladders show significantly more connective tissue and less muscle compared to normal bladders, even in developing fetuses. These changes are linked to neurogenic bladder dysfunction in children.

Area of Science:

  • Urology
  • Pediatric Urology
  • Developmental Biology

Background:

  • Neurogenic bladder dysfunction in children is commonly caused by myelodysplasia.
  • Histological characteristics of myelodysplastic bladders are not well-defined.
  • Understanding bladder tissue composition is crucial for managing dysfunction.

Purpose of the Study:

  • To investigate the relationship between smooth muscle and connective tissue in myelodysplastic bladders.
  • To compare histological features in control and myelodysplastic bladder specimens.
  • To characterize structural changes in the developing and mature myelodysplastic bladder.

Main Methods:

  • Classical morphometric analysis of bladder specimens.
  • Automated image analysis system for quantitative assessment.

Related Experiment Videos

  • Histological examination of fetal and patient bladder samples.

    • Main Results:

    • Myelomeningocele bladders exhibit reduced muscle bundles and increased connective tissue compared to controls.
    • Significant connective tissue infiltration of smooth muscle was observed in myelodysplastic bladders.
    • A 3-fold increase in connective tissue was noted in myelodysplastic bladders across different age groups.

    Conclusions:

    • Histological changes, including increased connective tissue, are present in myelodysplastic bladders from fetal development through adulthood.
    • These structural alterations likely contribute to detrusor morphology and neurogenic bladder dysfunction.
    • Findings enhance understanding of connective tissue's role in myelodysplastic bladder pathology.