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Numb: A new player in EMT.

Zezhou Wang1, Shawn S-C Li

  • 1Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CA.

Cell Adhesion & Migration
|February 20, 2010
PubMed
Summary
This summary is machine-generated.

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Numb protein plays a key role in epithelial to mesenchymal transition (EMT), influencing cell adhesion and migration. Its interaction with Par proteins and E-cadherin is crucial for regulating these processes during EMT.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Cancer Research

Background:

  • Epithelial to mesenchymal transition (EMT) is vital for embryogenesis and cancer metastasis.
  • Numb protein is known to influence Par protein complex function and cell-cell junctions, both implicated in EMT.

Purpose of the Study:

  • To elucidate the role of Numb in regulating epithelial to mesenchymal transition (EMT).
  • To investigate the interaction of Numb with Par3 and E-cadherin during EMT.

Main Methods:

  • Utilized shRNA to knockdown Numb expression in MDCK cells.
  • Analyzed the effects of Numb knockdown on E-cadherin and beta-catenin localization, F-actin polymerization, and cell migration.

Main Results:

  • Numb knockdown caused E-cadherin and beta-catenin translocation, increased F-actin polymerization, and mis-localization of Par3 and aPKC.

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  • Numb depletion resulted in decreased cell-cell adhesion and increased cell migration and proliferation.

    • Conclusions:

    • Numb plays a multifaceted role in regulating cell-cell adhesion, polarity, and migration during EMT.
    • The interaction of Numb with E-cadherin and Par proteins, modulated by phosphorylation, is critical for EMT processes.