Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 16, 2026

An Innovative Method for Exosome Quantification and Size Measurement
11:38

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

Design considerations in counting particles by size with an optical-digital training method.

H Stark, G Shao

    Applied Optics
    |February 20, 2010
    PubMed
    Summary

    An optical-digital computer was trained for particle-size analysis using diffracted light. This method effectively classifies particles by analyzing mixed slides, improving accuracy in size estimation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Population pharmacokinetics and dose evaluation for second-line TB drugs in patients with diabetes.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
    Same author

    Dexmedetomidine inhibits cerebral nerve cell apoptosis after cerebral hemorrhage in rats via the Nrf2/HO-1/NQO1 signaling pathway.

    European review for medical and pharmacological sciences·2022
    Same author

    The George Hospital theatre documentation and information system.

    South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2022
    Same author

    Genome-wide identification studies - A primer to explore new genes in plant species.

    Plant biology (Stuttgart, Germany)·2021
    Same author

    Epidemiological trends, predictive factors, and projection of tooth loss in Germany 1997-2030: part I. missing teeth in adults and seniors.

    Clinical oral investigations·2020
    Same author

    MicroRNA-15a inhibits inflammatory response and apoptosis after spinal cord injury via targeting STAT3.

    European review for medical and pharmacological sciences·2019

    Area of Science:

    • Optics
    • Computer Science
    • Materials Science

    Background:

    • Particle-size analysis is crucial in various scientific and industrial applications.
    • Traditional methods can be time-consuming and may lack precision.
    • Optical-digital computing offers a novel approach to complex analysis tasks.

    Purpose of the Study:

    • To present a technique for training an optical-digital computer for particle-size analysis.
    • To demonstrate the computer's ability to learn particle signatures from mixed samples.
    • To provide algorithms and design considerations for particle-size estimation.

    Main Methods:

    • Utilizing a coherent optical system to sample light diffracted from particles.
    • Training the optical-digital computer by analyzing diffracted light patterns from mixed slides.

    More Related Videos

    Methods for Measuring the Orientation and Rotation Rate of 3D-printed Particles in Turbulence
    12:34

    Methods for Measuring the Orientation and Rotation Rate of 3D-printed Particles in Turbulence

    Published on: June 24, 2016

    A Protocol for Real-time 3D Single Particle Tracking
    10:16

    A Protocol for Real-time 3D Single Particle Tracking

    Published on: January 3, 2018

    Related Experiment Videos

    Last Updated: Jun 16, 2026

    An Innovative Method for Exosome Quantification and Size Measurement
    11:38

    An Innovative Method for Exosome Quantification and Size Measurement

    Published on: January 17, 2015

    Methods for Measuring the Orientation and Rotation Rate of 3D-printed Particles in Turbulence
    12:34

    Methods for Measuring the Orientation and Rotation Rate of 3D-printed Particles in Turbulence

    Published on: June 24, 2016

    A Protocol for Real-time 3D Single Particle Tracking
    10:16

    A Protocol for Real-time 3D Single Particle Tracking

    Published on: January 3, 2018

  • Implementing and comparing two alternative algorithms for particle-size estimation.

    • Main Results:

    • The optical-digital computer successfully learned to distinguish between different particle classes.
    • The developed technique enables accurate particle-size analysis through diffracted light signatures.
    • Two distinct algorithms were presented for effective particle-size estimation.

    Conclusions:

    • The trained optical-digital computer provides an efficient and accurate method for particle-size analysis.
    • Analyzing diffracted light from mixed slides is a viable strategy for computer training.
    • The discussed algorithms and design considerations offer a foundation for practical implementation.