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Decrease of plasma platelet-activating factor acetylhydrolase activity in lipopolysaccharide induced mongolian gerbil

Junwei Yang1, Jing Xu, Xiaoying Chen

  • 1Department of Microbiology and Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.

Plos One
|February 20, 2010
PubMed
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Plasma PAF acetylhydrolase (pPAF-AH) activity changes during sepsis. Mongolian gerbils, unlike mice, show decreased pPAF-AH activity after LPS, mirroring human sepsis and offering a better model for therapy studies.

Area of Science:

  • Biomedical Science
  • Immunology
  • Pathophysiology

Background:

  • Sepsis pathogenesis involves Platelet-Activating Factor (PAF).
  • Plasma PAF acetylhydrolase (pPAF-AH) inactivates PAF, but its levels vary in human sepsis.
  • Existing rodent models show conflicting pPAF-AH responses to lipopolysaccharide (LPS).

Purpose of the Study:

  • To investigate the in vivo effect of LPS on pPAF-AH activity in C57BL/6 mice and Mongolian gerbils.
  • To identify a suitable animal model for studying pPAF-AH in human sepsis.

Main Methods:

  • Lipopolysaccharide (LPS) was administered to C57BL/6 mice and Mongolian gerbils.
  • Clinical manifestations were observed.
  • Plasma pPAF-AH activity was measured post-LPS treatment.

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Last Updated: Jun 16, 2026

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Main Results:

  • LPS-induced sepsis in C57BL/6 mice showed increased pPAF-AH activity.
  • LPS-induced sepsis in Mongolian gerbils showed decreased pPAF-AH activity, similar to human sepsis.
  • Clinical signs in both models were comparable.

Conclusions:

  • Mongolian gerbils represent a more appropriate LPS-induced sepsis model for studying pPAF-AH in relation to human sepsis.
  • This model may help elucidate mechanisms behind conflicting clinical trial outcomes for pPAF-AH-based sepsis therapies.