Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Exploration of sleep quality and rest-activity rhythms characteristics in Bilateral Vestibulopathy patients.

Sleep medicine·2024

Same author

Review of olfactory cleft roof anatomy.

European annals of otorhinolaryngology, head and neck diseases·2023

Same author

Paving the way to better understand the effects of prolonged spaceflight on operational performance and its neural bases.

NPJ microgravity·2023

Same author

Both whole-body rotation and visual flow induce cardiovascular autonomic response in human, but visual response is overridden by vestibular stimulation.

Scientific reports·2023

Same author

Selective optogenetic stimulation of glutamatergic, but not GABAergic, vestibular nuclei neurons induces immediate and reversible postural imbalance in mice.

Progress in neurobiology·2021

Same author

How to identify the anterior cribriform plate in the medial approach to the frontal sinus.

European annals of otorhinolaryngology, head and neck diseases·2020

Same journal

COMBINED ULTRA-HIGH FREQUENCY UNIT FOR IN-STREAM WATER PURIFICATION.

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2018

Same journal

METHOD FOR ANALYSIS OF HEART RATE REGULATION STRAIN BY APPLICATION OF THE OVERALL LOGARITHMIC INDEX TO THE HOLTER ELECTROCARDIOGRAM MONITORING.

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2018

Same journal

CLEANING OF METAL SURFACES FROM MICROORGANISMS-BIODESTRUCTORS BY COMBINED USE OF ULTRASOUND GENERATOR <<PASCAL>> AND AIR DECONTAMINATION UNIT <<POTOK>>.

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2018

Same journal

SPECIFICS OF GAS BUBBLE FORMATION AND GROWTH IN TISSUES DURING DECOMPRESSION AFTER SATURATION DIVES.

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2018

Same journal

SUBSTANTIATION OF OPTIMAL LIGHTING REGIMES FOR PLANTS IN SPACE GREENHOUSE <<VITACYCLE-T>>.

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2018

Same journal

CONTENT OF CYTOSKELETON PROTEINS IN OOCYTES OF THIRD GENERATION DROSOPHILA MELANOGASTER FRUIT FLIES OBTAINED AFTER A 44.5-DAY SPACE FLIGHT.

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2018

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Sympathetic B antagonist prevents bone mineral density decrease induced by labyrinthectomy.

P Denise¹, S Besnard, G Vignaux

¹Université de Caen Basse Normandie, Faculté de Médecine, Laboratoire de Physiologie, 14032 Caen Cedex, France.

Aviakosmicheskaia I Ekologicheskaia Meditsina = Aerospace and Environmental Medicine

|February 23, 2010

Summary

This summary is machine-generated.

Bilateral vestibular lesions in rats cause bone loss, but propranolol treatment prevents this. This suggests the sympathetic nervous system mediates vestibular system effects on bone density.

More Related Videos

Surgical Lumbar Sympathectomy in Mice

Surgical Lumbar Sympathectomy in Mice

Published on: July 5, 2024

Related Experiment Videos

Last Updated: Jun 16, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Surgical Lumbar Sympathectomy in Mice

Surgical Lumbar Sympathectomy in Mice

Published on: July 5, 2024

Area of Science:

Neuroscience
Bone Biology
Physiology

Background:

Bilateral vestibular lesions in rats are known to induce bone loss in weight-bearing bones.
The role of the sympathetic nervous system (SNS) in this bone loss is not fully understood.

Purpose of the Study:

To investigate whether the sympathetic nervous system mediates the bone loss induced by bilateral vestibular lesions.
To determine the effect of propranolol, a beta-blocker, on bone mineral density (BMD) following vestibular lesions.

Main Methods:

Four groups of female Wistar rats (n=10 per group) were used: bilateral labyrinthectomy (Bilab), Bilab with propranolol, sham operated, and sham operated with propranolol.
Bone mineral density (BMD) was measured 30 days after surgery.

Main Results:

Bilab rats exhibited significantly reduced BMD in the distal femoral metaphysis compared to intact rats (p < 0.001).
Propranolol treatment completely prevented the bone loss observed in Bilab rats.
No significant difference in BMD was found between sham-operated rats and Bilab rats treated with propranolol.

Conclusions:

The findings suggest that the sympathetic nervous system mediates the influence of the vestibular system on bone remodeling.
This research has potential implications for developing countermeasures against spaceflight-induced bone loss.