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The involvement of insulin in tryptamine-induced hypoglycemia in mice
Y Sugimoto1, I Kimura, J Yamada
1Department of Pharmacology, Kobe Women's College of Pharmacy, Japan.
Life Sciences
|January 1, 1991
Abstract:
The effects of tryptamine on plasma glucose and serum insulin levels were studied in mice. Tryptamine elicited dose-dependent hypoglycemia and hyperinsulinemia in intact mice. In streptozotocin-diabetic mice, tryptamine did not change plasma glucose nor serum insulin levels. Tryptamine significantly inhibited glucose-induced hyperglycemia and enhanced insulin release elicited by glucose. These results indicate that tryptamine-induced hypoglycemia is brought on by its releasing effects of insulin.