Related Experiment Video

Updated: Jun 16, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Asthma therapy during the first 8 years of life: a PIAMA cohort study

Mira G P Zuidgeest1, Ellen S Koster, Anke-Hilse Maitland-van der Zee

  • 1Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, 3508 TB Utrecht, The Netherlands.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|February 23, 2010
PubMed

Insights

Longitudinal asthma medication use in children is common, with many starting treatment before age 5. This study tracked medication patterns from birth to age 8 using pharmacy data.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Pharmacoepidemiology

Background:

  • Limited understanding of longitudinal asthma medication use patterns in children.
  • Cross-sectional studies do not capture the dynamic nature of treatment over time.

Purpose of the Study:

  • To establish a longitudinal dataset for studying childhood asthma medication use.
  • To determine the prevalence and incidence of asthma medication use from birth to age 8.
  • To describe initial patterns of medication initiation.

Main Methods:

  • Utilized the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) prospective birth cohort.
  • Integrated PIAMA data with comprehensive pharmacy records.
  • Ensured complete medication histories from birth to age 8 for analysis.

Main Results:

  • 36% of children received their first asthma medication prescription before age 8.
  • 88% of those initiating therapy did so before age 5.
  • Commonly prescribed medications included short-acting beta(2)-agonists (91.1%) and inhaled corticosteroids (61.1%).

Conclusions:

  • A robust dataset of 777 children with complete 8-year medication histories was created.
  • Asthma medication is initiated early in childhood, often before a definitive diagnosis.
  • The findings highlight the need for further research into early-life asthma treatment patterns.
Abstract

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...