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Published on: September 29, 2015
Chicken collagen hydrolysate protects rats from hypertension and cardiovascular damage
Youzuo Zhang1, Tomomi Kouguchi, Muneshige Shimizu
1R&D Center, Nippon Meat Packers Inc., Tsukuba, Ibaraki, Japan. y.zhang@nipponham.co.jp
Insights
Chicken collagen hydrolysate (CCH) effectively lowers blood pressure and improves vascular function. This study shows CCH ameliorates cardiovascular damage by regulating nitric oxide and reducing inflammation markers.
Area of Science:
- Cardiovascular Science
- Pharmacology
Background:
- Chicken collagen hydrolysate (CCH) exhibits angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects.
- Previous studies demonstrated CCH's efficacy in spontaneously hypertensive rats.
Purpose of the Study:
- To investigate the chronic effects of CCH on blood pressure and vascular relaxation.
- To evaluate CCH's impact on cardiovascular damage in a rat model induced by N-nitro-l-arginine methyl ester (L-NAME).
Main Methods:
- Wistar-Kyoto rats were induced with cardiovascular damage using L-NAME.
- Rats received co-treatment with CCH for 4 and 8 weeks.
- Measurements included systolic blood pressure, thoracic aorta vasorelaxation, soluble intercellular adhesion molecule-1 (ICAM-1), and nitric oxide levels.
Main Results:
- CCH significantly suppressed the increase in systolic blood pressure over 4 weeks.
- After 8 weeks, CCH significantly enhanced vasorelaxation and ameliorated cardiovascular damage.
- CCH reduced soluble ICAM-1 and increased nitric oxide concentrations.
Conclusions:
- CCH demonstrates antihypertensive effects and protects against endothelial cell damage.
- Its benefits stem from ACE inhibition, nitric oxide regulation, and reduction of ICAM-1.
- CCH shows potential as a medicinal food for cardiovascular disease patients.
Abstract:
We previously reported that chicken collagen hydrolysate (CCH) has strong angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects on spontaneously hypertensive rats. Here, we investigated the chronic therapy effects of CCH on blood pressure and vascular relaxation in a cardiovascular damage model of Wistar-Kyoto rats induced by N-nitro-l-arginine methyl ester (L-NAME). Following co-treatment with CCH for 4 weeks, the increment of systolic blood pressure was suppressed significantly. At 8 weeks, the vasorelaxation of thoracic aorta increased significantly, and cardiovascular damage was ameliorated. The concentration of soluble intercellular adhesion molecule-1 (ICAM-1) in blood was reduced significantly by long-term administration of CCH, whereas the nitric oxide concentration was increased significantly at 1 hour post-treatment. The results suggest that beneficial effects of CCH result from antihypertensive function, but also from inhibition of cardiovascular damage to the endothelial cells via its ACE inhibitory activity and regulation of nitric oxide and ICAM-1, which suggests that CCH may be useful as a medicinal food for patients with cardiovascular disease.
