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Related Experiment Video

Updated: Jun 16, 2026

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

Published on: April 7, 2014

Keratoconus associated with choroidal neovascularization: a case report.

Joo Youn Oh¹, Hyeong Gon Yu

¹Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. hgonyu@snu.ac.kr.

Journal of Medical Case Reports

|February 23, 2010

Summary

Keratoconus and choroidal neovascularization, linked to epithelial basement membrane dysfunction, can co-occur. This case suggests a potential shared pathogenesis between these distinct eye conditions.

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Area of Science:

Ophthalmology
Corneal diseases
Retinal diseases

Background:

Keratoconus and choroidal neovascularization (CNV) are distinct eye conditions.
Both conditions may arise from dysfunction of the epithelium and its basement membrane.
Understanding their potential co-occurrence is crucial for diagnosis and treatment.

Purpose of the Study:

To report a case of co-existing keratoconus and myopic choroidal neovascularization.
To investigate the potential link between the pathogenesis of these two conditions.

Main Methods:

Case report of a 17-year-old male with bilateral myopic CNV treated with intravitreal ranibizumab.
Clinical examination including corneal topography, fluorescein angiography, and optical coherence tomography.
Assessment of corneal steepening, stromal edema, subretinal hemorrhages, and lacquer cracks.

Main Results:

The patient presented with decreased vision and pain, indicative of advanced keratoconus with acute hydrops in the right eye.
Corneal topography confirmed keratoconus in both eyes.
Ocular imaging revealed bilateral myopic choroidal neovascularization with associated complications.

Conclusions:

Keratoconus and choroidal neovascularization can occur concurrently in the same individual.
The findings suggest a possible shared pathway in the pathogenesis of these conditions, potentially involving epithelial basement membrane dysfunction.