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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
[Pertussis in the Netherlands]
Sabine C de Greeff1, Hester E de Melker, Frits R Mooi
1RIVM, Centrum voor Infectieziektebestrijding, Afd. Epidemiologie en Surveillance, Bilthoven, The Netherlands. sabine.de.greeff@rivm.nl
Insights
Pertussis, or whooping cough, is increasing despite vaccinations. Protecting infants requires timely diagnosis, antibiotic treatment, and vaccinating adults and healthcare workers to prevent transmission.
Area of Science:
- Public Health
- Infectious Diseases
- Immunology
Context:
- Rising pertussis (whooping cough) incidence globally, particularly in adults.
- Severe pertussis complications and mortality risk in infants under three months.
- Contributing factors include waning immunity, pathogen adaptation, and increased awareness.
Purpose:
- To review current pertussis epidemiology and control strategies.
- To highlight the importance of vaccination updates and timely diagnosis.
- To emphasize strategies for preventing infant pertussis.
Summary:
- Pertussis incidence is increasing despite high vaccination rates, posing risks to unvaccinated infants.
- Waning immunity, pathogen evolution, and updated vaccination schedules are key considerations.
- Prompt diagnosis and antibiotic treatment, alongside targeted adult and healthcare worker vaccination, are crucial for infant protection.
Impact:
- Informing public health policies for pertussis control.
- Guiding vaccination strategies to protect vulnerable infant populations.
- Reducing pertussis morbidity and mortality in neonates and young children.
Abstract:
Despite high vaccination coverage, an increasing incidence of pertussis has been observed in recent years, especially among adults. Particularly in children less than three months of age, pertussis can lead to severe complications or even death. The increasing incidence of pertussis has been attributed to various factors, including increased awareness and waning vaccine-induced immunity in combination with pathogen adaptation. Changes in the vaccination schedule, the addition of a booster vaccination and an adjustment of the vaccine itself play an important part in handling this problem. A timely diagnosis of pertussis by a GP followed by antibiotic therapy can prevent potentially severe pertussis in young infants and avoid the spread of the bacteria. Targeting vaccination at adults and health care workers who are in close contact with infants may prevent transmission of pertussis to infants.
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