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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

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Published on: February 22, 2019

[Pertussis in the Netherlands].

Sabine C de Greeff1, Hester E de Melker, Frits R Mooi

  • 1RIVM, Centrum voor Infectieziektebestrijding, Afd. Epidemiologie en Surveillance, Bilthoven, The Netherlands. sabine.de.greeff@rivm.nl

Nederlands Tijdschrift Voor Geneeskunde
|February 23, 2010
PubMed
Summary
This summary is machine-generated.

Pertussis, or whooping cough, is increasing despite vaccinations. Protecting infants requires timely diagnosis, antibiotic treatment, and vaccinating adults and healthcare workers to prevent transmission.

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Immunology

Context:

  • Rising pertussis (whooping cough) incidence globally, particularly in adults.
  • Severe pertussis complications and mortality risk in infants under three months.
  • Contributing factors include waning immunity, pathogen adaptation, and increased awareness.

Purpose:

  • To review current pertussis epidemiology and control strategies.
  • To highlight the importance of vaccination updates and timely diagnosis.
  • To emphasize strategies for preventing infant pertussis.

Summary:

  • Pertussis incidence is increasing despite high vaccination rates, posing risks to unvaccinated infants.
  • Waning immunity, pathogen evolution, and updated vaccination schedules are key considerations.
  • Prompt diagnosis and antibiotic treatment, alongside targeted adult and healthcare worker vaccination, are crucial for infant protection.

Impact:

  • Informing public health policies for pertussis control.
  • Guiding vaccination strategies to protect vulnerable infant populations.
  • Reducing pertussis morbidity and mortality in neonates and young children.