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Related Concept Videos

Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Gluten sensitivity: from gut to brain.

Marios Hadjivassiliou1, David S Sanders, Richard A Grünewald

  • 1Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK. m.hadjivassiliou@sheffield.ac.uk

The Lancet. Neurology
|February 23, 2010
PubMed
Summary
This summary is machine-generated.

Gluten sensitivity, an autoimmune disorder, can cause neurological issues even without intestinal symptoms. Recent research explores these diverse neurological manifestations and diagnostic advancements.

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Area of Science:

  • Immunology
  • Neurology
  • Gastroenterology

Background:

  • Gluten sensitivity is a systemic autoimmune disorder triggered by gluten in susceptible individuals.
  • Coeliac disease is one manifestation, but neurological symptoms can occur independently.
  • Extraintestinal presentations of gluten sensitivity are increasingly recognized.

Purpose of the Study:

  • To review the spectrum of neurological manifestations associated with gluten sensitivity.
  • To discuss recent diagnostic progress in identifying gluten sensitivity-related neurological dysfunction.
  • To explore the underlying pathophysiological mechanisms of neurological impairment.

Main Methods:

  • Review of existing literature on gluten sensitivity and neurological disorders.
  • Analysis of case studies and clinical observations.
  • Synthesis of current research on diagnostic criteria and biomarkers.

Main Results:

  • Gluten sensitivity can present with a wide array of neurological symptoms.
  • Neurological dysfunction may be the sole manifestation of gluten sensitivity.
  • Advances in diagnosis are improving identification of affected individuals.

Conclusions:

  • Gluten sensitivity encompasses diverse neurological presentations beyond coeliac disease.
  • Early and accurate diagnosis of neurological gluten sensitivity is crucial.
  • Further research into pathophysiology will refine treatment strategies.